Assessment of extract of Carum Carvi on acute and chronic pain in mice in formalin test in mice

Few previous investigations show that Carum Carvi (CC) may control pain in both animal and human. The aim of this work was to assess the role of CC on acute and chronic pain in formalin test in mice. In this study male albino mice (25-30 g) were used. CC (100 and 500 mg/kg) and saline were injected 30 min before formalin test. Indexes of signs were licking and foot elavation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formalin 5% (25 µl) in right paw. Results indicated that CC has analgesic effect pain in both doses in acute and chronic phases and higher dose of the drug was more effective (P